Nano-encapsulation and characterization of baricitinib using poly-lactic-glycolic acid co-polymer
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چکیده
منابع مشابه
Synthesis and Characterization of Ursolic Acid Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles and Caffiene Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles in Colorectal Cancer Cell Line
Colorectal cancer is the fourth most frequently diagnosed cancer and the second leading cause of cancer death. About 96,830 new cases of colon cancer and approximately 40,000 cases of rectal cancer will occur and 50,310 people will die of colon and rectal cancer combined[1]. The long term survival rate of colon cancer patients treated by conventional modalities such as surgery, radiation, and c...
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Enhancing protein stability upon encapsulation and release from polymers is a key issue in sustained release applications. In addition, optimum drug dispersion in the polymer particles is critical for achieving release profiles with low unwanted initial "burst" release. Herein, we address both issues by formulating the model enzyme α-chymotrypsin (α-CT) as nanoparticles to improve drug dispersi...
متن کاملSpontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold
INTRODUCTION Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints. METHODS MSCs derived from hea...
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Nowadays, there are several efforts in immunotherapy especially biodegradable and biocompatible nano-polymers are using as immunomodulatory to induce cell mediated immune responses [1]. The advantages of nanoparticles have been proved to be potent immunomodulators in several kinds of vaccines to control a release of antigen, higher quality and quantity of immune responses and protect the integr...
متن کاملLoading of Gentamicin Sulfate into Poly (Lactic-Co-Glycolic Acid) Biodegradable Microspheres
Objective: In dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. In this study, gentamicin was loaded into polylactic co-glycolic acid (PLGA) microspheres and its release pattern was evaluated for 20 days. Methods: In this experimental study, PLGA microspheres loaded with gentamycin were produced by the W/O/W method....
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2019
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2019.01.012